INFORMATION FOR USE OF A MEDICALPRACTITIONER, HOSPITAL OR LABORATORY FEXOFENADINE Available CompositionFEXOL-LDEach film-coated tablet contains Fexofenadine Hydrochloride 120 mg PHARMACOLOGICAL CLASSIFICATION Antihistaminic (H1-receptor antagonist)MECHANISM OF ACTIONFEXOL-LD is an antihistamine with selective peripheral H1-receptor antagonist activity. Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects. Fexofenadine inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats. PHARMACOKINETICS FEXOL-LD is rapidly absorbed after oral administration with peak plasma concentrations being reached in 2 to 3 hours. It is about 60 to 70% bound to plasma proteins. About 5% of the total dose is metabolised, mostly by the intestinal mucosa, with only 0.5 to 1.5% of the dose undergoing hepatic biotransformation by the cytochrome P450 system. Elimination half-life of about 14 hours has been reported although this may be prolonged in patients with renal impairment. Excretion is mainly in the faeces with only 10% being present in the urine. Fexofenadine does not appear to cross the blood-brain barrier. INDICATIONS FEXOL-LD is indicated for the treatment of · Seasonal Allergic Rhinitis· Chronic Idiopathic Urticaria BEFORE YOU TAKE FEXOL-LDBefore taking the medicine always tells your doctor if you:· Are pregnant, trying for a baby or breast-feeding. · Have ever suffered from heart problems. · Suffer from epilepsy or porphyria (a blood disorder). · Have ever had an allergic reaction to this or any other medicine. HOW TO TAKE FEXOL-LD You must take your medicine as the doctor tells you. It is important to take FEXOL-LD Tablets at the right time. Your doctor will decide which is the best dose for you, depending on your illness. For the relief of the symptoms of seasonal and perennial allergic rhinitis (including hayfever) the usual dosage for adults and children over 12 years is one FEXOL-LD 60mg tablet twice daily, when required.For the relief of the symptoms of hayfever, the usual dosage for adults and children over 12 years of age is one FEXOL-LD 120mg tablet daily when required, or one FEXOL-LD 180mg tablet daily when required.For relief of the symptoms of urticaria, the usual dosage for adults and children over 12 years of age is one FEXOL-LD 180mg tablet daily when required. IF YOU MISS A DOSETake it as soon as you remember. If it is nearly time for the next dose, do not take the one you missed. Take the next dose at the usual time. Do not take a double dose to make up for the dose that you missed. If you miss more than one dose, or you are not sure what to do, ask your doctor or pharmacist. WHAT TO DO IF AN OVERDOSE IS TAKEN If you accidentally take too many tablets, contact your doctor or nearest hospital accident department immediately. The symptoms of an overdose are dizziness, tiredness/sleepiness, sickness and dry mouth. TAKING OTHER MEDICINE - Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription.
- Do not take FEXOL-LD close to a dose of an antacid that contains aluminum or magnesium such as Rolaids, Maalox, Mylanta, Milk of Magnesia, Pepcid Complete, and others. These antacids may decrease the effects of fexofenadine.
| SIDE EFFECTS - headache
- tiredness
- nausea
- dizziness
- drowsiness
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STORING - Keep out of the reach and sight of children.
- Keep your tablets in a dry & dark place.
- Do not store above 25°C.
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| Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
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