| Antiepileptic, Antidiabetic, Antianginal, Antifungal |
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Vetazidine
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INFORMATION FOR USE OF A MEDICAL PRACTITIONER, HOSPITAL OR LABORATORY |
Each film-coated tablet contains: Trimetazidine Hydrochloride BP 20mg |
Pharmacological Classification |
| Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these actions help the cell to restore the normal ionic and metabolic balance. |
Following oral administration blood levels reach a peak in 2-3 hours and then decrease gradually with a terminal half - life of about 6 hours. The bioavailability of orally administered trimetazidine is approximately 90 %. Food intake does not modify absorption. The major route of elimination is urinary, with about 60% of the administered dose being eliminated in the unchanged form. The rest is metabolized. Little is known of the properties of the metabolites, which are however only present in weak concentrations. Plasma Protein Binding: Approximately 16 % is bound to plasma proteins, chiefly albumin. |
| Vetazidine is indicated in the treatment of:· Ischaemic heart disease (angina pectoris, sequelae of infarction) |
BEFORE YOU TAKE VETAZIDINE |
BEFORE YOU TAKE VETAZIDINE |
| are pregnant, trying for a baby or breast-feeding · suffer from kidney problems · have ever had an allergic reaction to this or any other medicine· have renal disease · have hepatic disease |
| You must take your medicine as the doctor tells you. It is important to take VETAZIDINE at the right time. Your doctor will decide which is the best dose for you, depending on your illness. The recommended dose is one tablet thrice daily after meals. |
| Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your doses as you would normally. If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. |
WHAT TO DO IF AN OVERDOSE IS TAKEN |
In that case do not delay, ask your doctor immediately what to do or contact your nearest hospital emergency department. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription, your doctor may wish to alter your dose of VETAZIDINE if you are taking any of the following: · Beta-blockers, · Calcium antagonists,· Nitrates, heparin, · Hypolipidemic agents or digitalis |
The most common side effects include: · Gastric discomfort, · Nausea, headache and· Vertigo. However, the side effects are mild and non-specific. |
Store in a dry place at room temperature. Keep all medicines out of the reach of children. |
Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
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