|
| Antibiotic, Antibacterial, Penicellin, |
| |
Amoxicillin
|
|
| INFORMATION FOR USE OF A MEDICAL PRACTITIONER, HOSPITAL OR LABORATORY |
Each hard gelatin capsule contains: Amoxycillin trihydrate BP eq. to Amoxycillin 250 mg |
Each hard gelatin capsule contains: Amoxycillin trihydrate BP eq. to Amoxycillin 500 mg |
Each 5 ml of reconstituted suspension contains: Amoxicillin Trihydrate USP eq. to Amoxycillin 125 mg |
|
PHARMACOLOGICAL CLASSIFICATION |
Amoxicillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. Amoxicillin is resistant to inactivation by gastric acid. It is more rapidly and more completely absorbed than ampicillin when given by mouth. Peak plasma- amoxicillin concentrations of about 5 µg per ml have been observed 1 to 2 hours after a dose of 250 mg, with detectable amounts present for up to 8 hours. Doubling the dose can double the concentration. The presence of food in the stomach does not appear to diminish the total amount absorbed.About 20 % is bound to plasma proteins in the circulation and plasma half-lives of 1 to 1.5 hours have been reported. The half-life may be longer in neonates and the elderly: in renal failure the half-life may be 7 to 20 hours. Amoxicillin is widely distributed at varying concentrations in body tissues and fluids. It crosses the placenta; small amounts are distributed into breast milk, little amoxicillin passes into the CSF unless the meninges are inflamed.Amoxicillin is metabolized to a limited extent to penicilloic acid which is excreted in the urine. About 60 % of an oral dose of amoxicillin is excreted unchanged in the urine in 6 hours by glomerular filtration and tabular secretion. Urinary concentrations above 300 µg per ml have been reported after a dose of 250 mg. V-MOX (Amoxicillin) is indicated for the treatment of: |
· acute otitis media, · pharyngitis, · pneumonia, · sinusitis and urinary tract infections |
Caused by susceptible organisms |
| Make sure you have told your doctor if you: |
· are pregnant, trying for a baby or breast-feeding · suffer from kidney problems · have glandular fever · have ever had an allergic reaction to this or any other medicine · a bleeding or blood clotting disorder; · mononucleosis (also called "mono"); · a history of diarrhea caused by taking antibiotics |
You must take your medicine as the doctor tells you. It is important to take V-MOX at the right time. Your doctor will decide which is the best dose for you, depending on your illness. | Neonates and Infants Aged ≤12 Weeks (≤3 Months) |
Due to incompletely developed renal function affecting elimination of amoxicillin in this age group, the recommended upper dose of amoxicillin is 30 mg/kg/day divided q12h.Adults-Usually 500 mg every 12 hours or 500 mg every 8 hours depending on the severity of the diseas |
Pediatric Patients >3 Months-45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours depending on the severity of the disease |
Swallow each V-MOX whole with water. Do not chew, crush, or split. If you are taking amoxicillin with clarithromycin and/or lansoprazole to treat stomach ulcer, use all of your medications as directed. You may take amoxicillin with or without food. Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your doses as you would normally. If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. WHAT TO DO IF AN OVERDOSE IS TAKEN |
In that case do not delay, ask your doctor immediately what to do or contact your nearest hospital emergency department. Overdose symptoms may include confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure (black-out or convulsions). Do this even if there are no signs of discomfort or poisoning. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription, your doctor may wish to alter your dose of V-MOX if you are taking any of the following: · Allopurinol · Methotrexate · Combined oral contraceptives Probenecid |
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Consult your doctor at once if you have any of these serious side effects: - fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- diarrhea that is watery or bloody;
- fever, chills, body aches, flu symptoms;
- easy bruising or bleeding, unusual weakness;
- urinating less than usual or not at all;
- agitation, confusion, unusual thoughts or behavior; or
- Seizure (black-out or convulsions).
|
Less serious side effects are more likely to occur, such as: - nausea, vomiting, stomach pain;
- vaginal itching or discharge;
- headache;
- swollen, black, or "hairy" tongue; or
- Thrush (white patches or inside your mouth or throat).
|
- Store in a dry place at room temperature.
- Keep all medicines out of the reach of children.
|
Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
|
|
| |
| |
|
|
|
