| Antibiotic, Antibacterial, Penicellin, |
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Ampicillin
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INFORMATION FOR USE OF A MEDICAL PRACTITIONER, HOSPITAL OR LABORATORY |
| AMPICILLIN CAPSULE/DRY SYP |
Each hard gelatin capsules contains: Ampicillin Trihydrate IP |
| Each 5 ml of reconstituted suspension contains: Ampicillin Trihydrate USP |
PHARMACOLOGICAL CLASSIFICATION |
Belonging to the penicillin group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. It differs from penicillin only by the presence of an amino group. That amino group helps the drug penetrate the outer membrane of gram-negative bacteria. Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase. Transpeptidase is needed by bacteria to make their cell walls. It inhibits the third and final stage of bacterial cell wall synthesis, which ultimately leads to cell lysis. Ampicillin is relatively resistant to inactivation by gastric acid and is moderately well absorbed from the gastrointestinal tract after oral administration. Food can interfere with the absorption of ampicillin so doses should preferably be taken at least 30 minutes before meals. Peak concentrations in plasma are attained in about 1 to 2 hours and following a dose of 500 mg by mouth are reported to range from 2 to 6 µg per ml. Ampicillin is widely distributed and therapeutic concentration can be achieved in ascetic, pleural, and joint fluids. It crosses the placenta into the fetal circulation and small amounts are distributed into breast milk. About 20% is bound to plasma proteins and the plasma half-life is about 1 to 1.5 hours. Ampicillin is metabolized to some extent to penicilloic acid which is excreted in the urine. V-CILLIN is indicated for the treatment of: |
Make sure you have told your doctor if you: |
Are pregnant or think you may be pregnant, or are planning to become pregnant. Are breast feeding. Are allergic to ampicillin, penicillin, or any other drugs.You have or have ever had kidney or liver disease, allergies, asthma, blood disease, colitis, stomach problems, or hay fever. |
You must take your medicine as the doctor tells you. It is important to take V-CILLIN Tablets at the right time. Your doctor will decide which is the best dose for you, depending on your illness. |
Adults and Children Weight Over 20 kg |
The usual dose is 500 mg qid in equally spaced doses; severe or chronic infections may require larger doses. |
Children Weighing 20 kg or Less |
For genitourinary or gastrointestinal tract infections, the usual dose is 100 mg/kg/day total, qid in equally divided and spaced doses. For respiratory infections, the usual dose is 50 mg/kg/day total, in equally divided and spaced doses three to four times daily. Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your doses as you would normally. If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. WHAT TO DO IF AN OVERDOSE IS TAKEN |
In that case do not delay, ask your doctor immediately what to do or contact your nearest hospital emergency department. Do this even if there are no signs of discomfort or poisoning. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription, your doctor may wish to alter your dose of V-CILLIN if you are taking any drug: · Allopurinol · Anticoagulants (blood thinners) such as warfarin, · Atenolol, oral contraceptives · Probenecid, · Rifampin, · Sulfasalazine |
Like all medicines, V-CILLIN can cause side effects: common side effects include: - upset stomach
- diarrhea
- vomiting
mild skin rash
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If you experience any of the following symptoms, call your doctor immediately: · Keep all medicines out of the reach of children. · Store at room temperature(20 to 25°C) |
Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
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