| Antibiotic, Antibacterial, Penicellin, |
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Cefadroxil
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INFORMATION FOR USE OF A MEDICAL PRACTITIONER, HOSPITAL OR LABORATORY |
| CEFADROXIL CAPSULE/DRY SYP |
Each hard gelatin capsules contains: Cefadroxil IP/USP |
Eq. to Cefadroxil(Anhydrous) 250 mg |
Each 5 ml of reconstituted suspension contains: Cefadroxil IP/USP |
| Eq. to Cefadroxil(Anhydrous) 125 mg |
PHARMACOLOGICAL CLASSIFICATION |
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin. Cefadroxil is a broad-spectrum antibiotic effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic. All cephalosporins are bactricidal and have the same mechanism of action as penicillin, i.e. inhibition of bacterial cell wall synthesis. Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.
Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.
More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. CEFADROXIL is indicated for the treatment of: |
· Urinary tract infections caused by E. coli, P. mirabilis, and Klebsiella species. · Skin and skin structure infections caused by staphylococci and/or streptococci. · Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes |
BEFORE YOU TAKE CEFADROXIL |
Make sure you have told your doctor if you: |
Are pregnant or think you may be pregnant, or are planning to become pregnant. Are breast feeding. are allergic to cefadroxil or any other cephalosporin antibiotic have or have ever had kidney or liver disease, colitis, or stomach problems
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You must take your medicine as the doctor tells you. It is important to take CEFADROXIL Tablets at the right time. Your doctor will decide which is the best dose for you, depending on your illness. Urinary Tract Infections: For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in a single (q.d.) or divided doses (b.i.d.). For all other urinary tract infections the usual dosage is 2 g per day in divided doses (b.i.d.).Skin and Skin Structure Infections: For skin and skin structure infections the usual dosage is 1 g per day in single (q.d.) or divided doses (b.i.d.). Pharyngitis and Tonsillitis: Treatment of group a beta-hemolytic streptococcal pharyngitis and tonsillitis-1 g per day in single (q.d.) or divided doses (b.i.d.) for 10 days. For urinary tract infections, the recommended daily dosage for children is 30 mg/kg/day in divided doses every 12 hours. For pharyngitis, tonsillitis, and impetigo, the recommended daily dosage for children is 30 mg/kg/day in a single dose or in equally divided doses every 12 hours. For other skin and skin structure infections, the recommended daily dosage is 30 mg/kg/day in equally divided doses every 12 hours. In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of Cefadroxil should be administered for at least 10 days. Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your doses as you would normally. If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. WHAT TO DO IF AN OVERDOSE IS TAKEN |
In that case do not delay, ask your doctor immediately what to do or contact your nearest hospital emergency department. Do this even if there are no signs of discomfort or poisoning. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription, your doctor may wish to alter your dose of CEFADROXIL if you are taking any drug: · Anticoagulants (blood thinners) such as warfarin · Probenecid· Vitamins · furosemide |
| Like all medicines, CEFADROXIL can cause side effects: common side effects include: |
If you experience any of the following symptoms, call your doctor immediately: - severe skin rash
- itching
- hives
- difficulty breathing or swallowing
- wheezing
- unusual bleeding or bruising
- sore throat
- painful mouth or throat sores
- vaginal infection
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· Keep all medicines out of the reach of children. ·Store at room temperature(20 to 25°C) |
| Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
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