| Antibiotic, Antibacterial, Penicellin, |
| |
Cloxacillin
|
|
INFORMATION FOR USE OF A MEDICAL PRACTITIONER, HOSPITAL OR LABORATORY |
Each hard gelatin capsules contains: Cloxacillin Sodium USP eq. to Cloxacillin250 mg |
Each hard gelatin capsules contains: Cloxacillin Sodium USP eq. to Cloxacillin500 mg |
PHARMACOLOGICAL CLASSIFICATION |
Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested. V-CLOX is slowly absorbed from the gastrointestinal tract. The Oral absorption is ~50%. Widely distributed to most body fluids and bone; penetration into cells, into eye, and across normal meninges is poor; crosses placenta; enters breast milk; inflammation increases amount that crosses blood-brain barrier. The Protein binding is 90% to 98%. Metabolism: Extensively hepatic to active and inactive metabolites. Half-life elimination: 0.5-1.5 hours; prolonged with renal impairment and in neonates and mainly Excreted through Urine and feces V-CLOX is indicated for the treatment of: |
· respiratory tract infection, · skin and skin structure infection, · bone and joint infection, · urinary tract infections |
Make sure you have told your doctor if you: |
Are pregnant or think you may be pregnant, or are planning to become pregnant. - Are breast feeding.
are allergic to cloxacillin or any other penicillin antibiotic have or have ever had kidney or liver disease, colitis, or stomach problems
|
You must take your medicine as the doctor tells you. It is important to take V-CLOX Tablets at the right time. Your doctor will decide which is the best dose for you, depending on your illness. The recommended dose is:Children >1 month (<20 kg): 50-100 mg/kg/day in divided doses every 6 hours; up to a maximum of 4 g/day Children (>20 kg) and Adults: 250-500 mg every 6 hours Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your doses as you would normally. If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. WHAT TO DO IF AN OVERDOSE IS TAKEN |
In that case do not delay, ask your doctor immediately what to do or contact your nearest hospital emergency department. Do this even if there are no signs of discomfort or poisoning. Symptoms of an cloxacillin overdose include muscle spasms or weakness, pain or twitching, pain in the fingers or toes, loss of feeling in the fingers or toes, seizures, confusion, coma, and agitation. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription, your doctor may wish to alter your dose of V-CLOX if you are taking any drug: Like all medicines, V-CLOX can cause side effects: common side effects include: |
- mild nausea, vomiting, diarrhea, or abdominal pain;
white patches on the tongue (thrush/yeast infection); itching or discharge of the vagina (vaginal yeast infection); or Black, "hairy" tongue or sore mouth or tongue
|
If you experience any of the following symptoms, call your doctor immediately: |
|
· Keep all medicines out of the reach of children. · Store at room temperature(20 to 25°C) |
Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
|
|
| |
| |
|
