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| Antiepileptic, Antidiabetic, Antianginal, Antifungal |
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Nitroglycerine
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INFORMATION FOR USE OF A MEDICAL PRACTITIONER, HOSPITAL OR LABORATORY |
| Each uncoated tablet contains: Diluted Nitroglycerin USP eq. to Nitroglycerin 0.5 mg |
| PHARMACOLOGICAL CLASSIFICATION |
Nitroglycerin forms free radical nitric oxide (NO) which activates guanylate cyclase, resulting in an increase of guanosine 35 monophosphate (cyclic GMP) in smooth muscle and other tissues. These events lead to dephosphorylation of myosin light chains, which regulate the contractile state in smooth muscle, and result in vasodilatation. |
| Nitroglycerin is rapidly absorbed following sublingual administration of Nitrostat tablets. Mean peak nitroglycerin plasma concentrations occur at a mean time of approximately 6 to 7 minutes postdose. Maximum plasma nitroglycerin concentrations (Cmax) and area under the plasma concentration-time curves (AUC) increase dose-proportionally following 0.3 to 0.6 mg Nitrostat. The absolute bioavailability of nitroglycerin from Nitrostat tablets is approximately 40% but tends to be variable due to factors influencing drug absorption such as sublingual hydration and mucosal metabolism. |
| · Prevention of angina pectoris due to coronary artery disease |
| Make sure you have told your doctor if you: |
- Are pregnant or think you may be pregnant, or are planning to become pregnant.
- Are breast feeding.
- are allergic to nitroglycerin, isosorbide mononitrate, or isosorbide dinitrate
- early signs of a heart attack
- severe anemia
- a brain injury, hemorrhage, or tumor
- low blood pressure;
- glaucoma;
- migraine headaches;
- Liver disease.
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| Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.If possible, try to rest or stay seated when you use this medication. Nitroglycerin can cause dizziness or fainting.The nitroglycerin sublingual tablet should be placed under your tongue and allowed to dissolve slowly. Do not chew or swallow it.It is important to keep this medicine on hand at all times in case of an angina attack. Get your prescription refilled before you run out of medicine completely.If you take nitroglycerin on a regular schedule to prevent angina, do not stop taking it suddenly or you could have a severe attack of angina. |
Since nitroglycerin is often used only as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. Do not take a double dose to make up for the dose that you missed. WHAT TO DO IF AN OVERDOSE IS TAKEN |
In that case do not delay, ask your doctor immediately what to do or contact your nearest hospital emergency department. Do this even if there are no signs of discomfort or poisoning. Overdose symptoms may include a severe throbbing headache, confusion, fever, fast or pounding heartbeats, dizziness, vision problems, nausea, vomiting, bloody diarrhea, trouble breathing, cold or clammy skin, feeling light-headed, fainting, and seizures. | · Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription, your doctor may wish to alter your dose of NYROCIN if you are taking any drug: · alteplase · aspirin or heparin;· bladder or urinary medications such as oxybutynin or tolterodine · blood pressure medication;· bronchodilators such as ipratropium or tiotropium· dihydroergotamine or ergotamine· an erectile dysfunction medication such as Sildenafil, tadalafil or vardenafil · antidepressants such as amitriptyline, clomipramine , imipramine,· a beta-blocker such as atenolol, carvedilol , metoprolol ,nadolol, propranolol, sotalol.· a calcium channel blocker such as diltiazem , nifedipine, nimodipine , verapamil.· irritable bowel medications such as dicyclomine, hyoscyamine, or propantheline;· any medication that causes dry mouth; or · medicines to treat psychiatric disorders, such as chlorpromazine, haloperidol, thioridazine |
Like all medicines, NYROCIN can cause side effects. Common side effects include: - mild burning or tingling with the tablet in your mouth;
- warmth, redness, or tingly feeling under your skin; or
- feeling weak or dizzy.
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If you experience any of the following symptoms, call your doctor immediately: - fast, slow, pounding, or uneven heart rate;
- blurred vision or dry mouth;
- feeling light-headed, nausea, vomiting, sweating, pale skin fainting; or
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.
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· Keep all medicines out of the reach of children. · Nitroglycerin tablets in the glass container at room temperature, away from moisture and heat. |
| Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
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