Paracetamol is a p-aminophenol derivative that exhibits analgesic and antipyretic activity. It inhibits the synthesis of prostaglandins in the central nervous system and peripherally blocks pain impulse generation; produces antipyresis from inhibition of hypothalamic heat-regulating center.  

Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral administration. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma protein binding is negligible at usual therapeutic concentration but increases with increasing concentrations. The elimination half life of paracetamol varies from about 1 to 3 hours.Paracetamol is metabolized predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged paracetamol. A minor hydroxylated metabolite (N-acetyl-p-benzoquinoneimine), which is usually produced in very small amounts by mixed function oxidases in the liver and kidney and which is usually detoxified by conjugation with glutathione, may accumulate following paracetamol over dosage and cause tissue damage.   

headache, toothache, mild and moderate postoperative and injury pain, high temperature, infectious diseases and chills (acute catarrhal inflammations of the upper respiratory tract, flu, small-pox, parotitis, etc.).          

• have ever had an allergic reaction to Paracetamol Tablets or any of the ingredients in the tablet. An allergic reaction may include a rash, itching, difficulty breathing or swelling of the face, lips, throat or tongue.

Ask your doctor or pharmacist for advice before taking Panamol._{HOW TO TAKE PANAMOL}

Follow your doctor’s instructions. Check the pharmacy label to see how many tablets to take and how often to take them.If you are still unsure ask your pharmacist or doctor. 

The usual adult dose by mouth is 0.5 to 1 g every 4 to 6 hours up to a maximum of 4 g daily. Usual doses in children are: under 3 months, 10 mg/kg (reduce to 5 mg/kg if jaundiced); 3 months to 1 year, 60 to 120 mg; 1 to 5 years, 120 to 250 mg; 6 to 12 years, 250 to 500 mg. These doses may be given every 4 to 6 hours when necessary up to a maximum of 4 doses in 24 hours. For post-immunisation pyrexia, a dose of 60 mg has been recommended for children 2 to 3 months of age. A second dose may be given after four to six hours; if the pyrexia persists after that dose, medical advice should be sought. Patients weighing over 50 kg, single doses of 1 g every 4 or more hours, to a maximum of 4 g daily From 33 to 50 kg, single doses of 15 mg/kg every 4 or more hours, to a maximum of 60 mg/kg or 3 g daily (whichever is less) Between 10 and 33 kg, single doses of 15 mg/kg every 4 or more hours, to a maximum of 60 mg/kg or 2 g daily.Swallow these tablets with water. Take this medicine for as long as your doctor tells you to. 

IF YOU MISS A DOSE    If you forget to take a tablet take one as soon as you remember, unless it is nearly time to take the next one. Never take two doses together. Take the remaining doses at the correct time.

If you swallow a lot of the tablets at the same time, or if you think a child has swallowed any of the tablets, contact your nearest hospital casualty department or your doctor immediately. Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.