| Anti-Rheumatic Drug, Antimicrobial |
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Nitrofurantoin
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INFORMATION FOR USE OF A MEDICAL PRACTITIONER, HOSPITAL OR LABORATORY |
Each coated tablet contains Nitrofurantoin USP 100mg |
PHARMACOLOGICAL CLASSIFICATION |
Antimicrobial (Urinary Tract Antiseptics) |
NYRO MAC, a synthetic, broad-spectrum, weakly acidic antibacterial, is generally bactericidal at therapeutic concentrations. Therapeutic concentrations are achieved only in the urine. The mechanism of antimicrobial action is unique among antibacterials. Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates, which inactivate or alter bacterial ribosomal proteins and other macromolecules. These inactivations or alterations of bacterial ribosomal proteins and macromolecules cause the inhibition of vital biochemical processes of aerobic energy metabolism and the syntheses of bacterial deoxyribonucleic acid (DNA), ribonucleic acid (RNA), cell wall, and protein. The fact that nitrofurantoin interferes with a variety of bacterial processes may explain the lack of acquired bacterial resistance to nitrofurantoin. The multiple and simultaneous mutations of the target macromolecules that would be required to achieve resistance would probably be lethal to the bacteria. NYRO MAC is readily absorbed from the gastrointestinal tract. The absorption rate is dependent on crystal size. The macrocrystalline form has slower dissolution and absorption rates, produces lower serum concentration than the microcrystalline form, and takes longer to achieve peak concentration in the urine. The presence of food in the gastrointestinal tract may increase the bioavailability of Nitrofurantoin and prolong the duration of therapeutic urinary concentrations. NYRO MAC is indicated for the treatment of uncomplicated lower Urinary Tract Infections (UTI) when due to susceptible strains of: · E. coli, enterococci, · S. aureus · Klebsiella species, · Enterobacter species and · Proteus species |
| BEFORE YOU TAKE NYRO MACMake sure you have told your doctor if you: |
· are pregnant, trying for a baby or breast-feeding · have glucose 6-phosphate dehydrogenase (G6PD) deficiency or if you have a family history of this condition · suffer from liver or kidney problems · suffer from anaemia, diabetes, deficiencies of vitamin B or folic acid or porphyria (blood disorder) · have lung problems or breathing difficulties · suffer with circulatory problems, particularly in the hands and feet · have ever had an allergic reaction to this or any other medicine · are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines |
You must take your medicine as the doctor tells you. It is important to take NYRO MAC Tablets at the right time. Your doctor will decide which is the best dose for you, depending on your illness. The usual adult dose for treatment of active infections is 50-100 mg four times daily for seven days. The usual adult dose for prevention of infections is 50-100 mg at bedtime. But this may be changed by your doctor. Carefully follow all the directions given to you by your doctor.
NYRO MAC should be taken with food or milk. Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your doses as you would normally. If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. WHAT TO DO IF AN OVERDOSE IS TAKEN |
In that case do not delay, ask your doctor immediately what to do or contact your nearest hospital emergency department. Do this even if there are no signs of discomfort or poisoning. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription, your doctor may wish to alter your dose of NYRO MAC if you are taking any of the following: Like all medicines, NYRO MAC can sometimes cause unwanted side effects · Nausea, · Headache, and · Flatulence |
Inform your doctor if you notice any of the following: · severe abdominal pain · numbness or tingling in the fingers or toes · visual disturbances · taste disturbances · dizziness or vertigo · drowsiness or malaise · rash · swelling of the face, lips, mouth, tongue or throat · joint or muscle pain · fever or chills · cough, chest pain or difficulty in breathing · jaundice |
· Keep all medicines out of the reach of children. · Store in a cool, dry place, away from direct heat and light · Never keep out of date or unwanted medicines. Discard them safely out of the reach of children or take them to your local pharmacist who will dispose of them for you. |
| Disclaimer: Strictly meant for information purpose only. The above information should not be used at one’s own discretion nor should substitute your physician’s advice. |
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