Each film coated tablet contains Clopidogrel Bisulphate USP….75 mg

 

PHARMACOLOGICALCLASSIFICATION

The mechanism of action of CLOGREL-75 is an irreversible blockade of the adenosine diphosphate (ADP) receptor on platelet cell membranes. This receptor is named P2Y12 and is important in platelet aggregation, the cross-linking of platelets by fibrin. The blockade of this receptor inhibits platelet aggregation by blocking activation of the glycoprotein IIb/IIIa pathway.

 CLOGREL-75 is rapidly but incompletely absorbed following oral administration; absorption appears to be about 50%. It is a prodrug and is extensively metabolized in the liver following absorption, mainly to the inactive carboxylic acid derivative. The active metabolite appears to be a thiol derivative but has not been identified in plasma. Clopidogrel and the carboxylic acid derivative are highly protein bound. Clopidogrel and its metabolites are excreted about equally in urine and in faeces. 

IF YOU MISS A DOSETake it as soon as you remember. If it is nearly time for the next dose, do not take the one you missed. Take the next dose at the usual time.  Do not take a double dose to make up for the dose that you missed.  

WHAT TO DO IF AN OVERDOSE IS TAKEN

  If you accidentally take too many tablets, contact your doctor or nearest hospital accident department immediately. TAKING OTHER MEDICINE

·          Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

·          The use of warfarin (a drug used to reduce blood clotting) with clogrel-75 is not recommended.

·          You should specifically tell your doctor if you take a non-steroidal anti-inflammatory medicinal product, usually used to treat painful and/or inflammatory conditions of muscle or joints, or if you take heparin, another drug used to reduce blood clotting 

Like all medicines, CLOGREL-75 can cause side effects,The most common side effect reported with CLOGREL-75 is bleeding such as bruising, haematoma (unusual bleeding or bruising under the skin), nose bleed, bleeding in the stomach or bowels. In a small number of cases bleeding in the eye, inside the head, the lung or the joints has also been reported.The other side effects reported with Clogrel-75 are:

• Diarrhoea, abdominal pain, constipation, nausea, vomiting, indigestion or heartburn, inflammation of the mouth (stomatitis);
• Vertigo, headache, decrease in blood pressure, confusion, hallucinations;
• Skin disorders such as rashes and itching, swelling in the mouth, blisters of the skin, generalised allergic reactions;
• Joint pain, muscular pain, fever, taste disorders;
• Breathing difficulties, sometimes associated with cough
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  Contact your doctor immediately if you experience:

• Fever, signs of infection or extreme tiredness. These may be due to rare decreases of some blood cells
• Signs of liver problems such as yellowing of the skin and/or eyes (jaundice), whether or not associated with bleeding and/or confusion. 

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  STORING

•                Keep all medicines out of the reach of children.
•               Store in a cool, dry place, away from direct heat and light.